SELP and atrial fibrillation: Among the molecular functions attributed to reduced expression of this miR in AF are (i) the increased expression of pro-fibrotic markers, (ii) a reduction in the inward rectifying K+ channel KNJ2 and dysregulation of L-type Ca2+ channels, contributing to arrhythmogenesis, and (iii) a reduction in the SELP protein, which increases the risk of thrombosis and an increase in the risk of cardioembolic strokes [124].