Numerous studies have demonstrated a positive correlation between thrombomodulin and hs-CRP levels and the recurrence of AF following cardioversion or ablation: Serum levels of high-sensitivity C-reactive protein (hs-CRP), a measure of vascular inflammation, and soluble thrombomodulin, which controls thrombosis on the surface of endothelial cells, had a strong correlation with primary (pri)-miR-126, the levels of which were restored after CA [142]. This evidence concerns the gene THBD and atrial fibrillation.