Between 2013 and 2022, SCN5A was sequenced as part of the genetic analysis of 452 consecutive probands (72% male; age at diagnosis 50 ± 18 years; 5% pediatric cases, younger than 15 years) evaluated in the unit for inherited cardiovascular diseases of the Hospital Universitario de Salamanca (Spain), resulting in 11 actionable SCN5A variants. Here, SCN5A is linked to cardiovascular disorder.