2) affect its expression or activity and may contribute to the development of many cancers, with CX3CR1 acting as one of the transactivators of ErbB-1 and ErbB-2 (see Chapter 5 on the FKN/CX3CR1 axis and tumorigenesis) [102,177,178,179,180,181]. The gene discussed is CX3CR1; the disease is cancer.