TNF and neoplasm: Chemotherapeutics such as bleomycin, camptothecin and 5-fluorouracil can induce apoptosis, autophagy and cell cycle arrest in tumor cells by inhibiting DNA synthesis and interfering with RNA. Metabolites of mitomycin C also interfere with the synthesis of DNA, RNA and proteins [95,96,97,122]. Liposomal paclitaxel can suppress the production of TNF-α, IL-6 and TGF-β and inhibit the expression of α-SMA and collagen I in human KD fibroblast [133]. Tamoxifen decreases the expression of TGF-β1, with the consequent inhibitions of both fibroblast proliferation and collagen production [135].