UCP1 and obesity due to melanocortin 4 receptor deficiency: On the other hand, BAT activation and WAT browning have anti-obesity effects and different factors involved in this process have been discussed: UCP-1 activators, cold exposure, exercise, a diet enriched in MUFAs and PUFAs, an improvement in the intestinal microbiota populations, and supplements with natural or herbal products as polyphenols, among others.