This study revealed a system-wide effect of nutlin-3a on 4037 differentially affected proteins, uncovering diverse pathways perturbed by p53 activation (PI3K/mTOR pathway, heat-shock response, glycolysis, etc.)Moreover, the identification of synergistic apoptotic effects upon the combined inhibition of the HSP90 or PI3K/mTOR pathway with nutlin-3a-induced p53 activation suggested a promising therapeutic strategy against lymphomas [102]. This evidence concerns the gene TP53 and lymphoma.