There are many risk factors for AD and, among others, they are age, genetics (APOE-e4, Down syndrome, genetic mutations of the APP gene and genes for presenilin-1 and presenilin-2, and a first-degree relative with AD), smoking, obesity, hypertension, high cholesterol levels, diabetes, diet, low physical activity, lower socioeconomic status, and poor sleep quality. This evidence concerns the gene PSEN1 and Alzheimer disease.