In the present study, we determined the levels of selected pro- and anti-inflammatory cytokines (IL-1α, IL-1β, IL-12, IL-10, as well as C reactive protein), markers of the redox status (glutathione reductase, glutathione peroxidase, superoxide dismutase, and total antioxidant status), as well as the metabolomic profile in the large intestine tissue of rats with AOM-induced early stage of colorectal cancer. Here, GSR is linked to infectious otitis media.