BRCA2 and pachyonychia congenita: In metastatic PC, a germline P/LPV in DDR-associated genes is detectable in about 12% of patients, mainly in BRCA2 (5.3%), ATM (1.6%), CHEK2 (1.9%), BRCA1 (0.9%), RAD51D (0.4%), PALB2 (0.4%), and ATR (0.3%) [5].