Furthermore, according to the KEGG pathway enrichment analysis, all the DEGs and upregulated DEGs were significantly enriched in more than 10 signaling pathways (p < 0.05), mainly involving metabolism-related pathways such as glycolysis/gluconeogenesis, HIF-1 signaling pathway, central carbon metabolism in cancer, carbon metabolism, and biosynthesis of amino acids (Figure 2G,H). Here, HIF1A is linked to cancer.