YWHAQ and Alzheimer disease: AD-specific neuropathology consists of extracellular amyloid plaques arising from the accumulation of amyloid beta protein (Aβ, A) and intracellular neurofibrillary tangles formed by aggregations of hyperphosphorylated tau protein (Ptau, T) [1], while neurodegeneration (N), the third neuropathological aspect of AD, is a nonspecific hallmark and can be caused by several neurodegenerative diseases.