The Alox15 gene, an ortholog of the human ALOX12 gene, develops the myeloproliferative disease characterized by pancytopenia attributed to hematopoietic stem cell dysfunction at the asymptomatic stage, followed by an abnormal expansion of myeloid cells in the spleen and bone marrow [24,25]. The gene discussed is ALOX12; the disease is myeloproliferative disorder.