In addition, factors such as GLP1/PYY and TGR5 may also play a role in the anti-obesity effect of L. acidophilus H-68, and we plan to explore the potential mechanisms of L. acidophilus H-68 or other novel anti-obesity probiotics in depth from these dimensions in the future. Here, GPBAR1 is linked to obesity due to melanocortin 4 receptor deficiency.