ALS exhibits aggregates of mutant superoxide dismutase 1 (SOD1), TAR DNA binding protein 43 (TDP-43), fused in sarcoma (FUS), and repeated dipeptides resulting from the non-canonical translation of mutant chromosome 9 open reading frame 72 (C9ORF72). The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.