HSPB1 and tauopathy: Recently, indole compound 36 (NC009-1, Figure 22) has demonstrated the capability to reduce Aβ-aggregation and provide neuroprotective effects through the activation of heat shock protein beta 1 (HSPB1) in a cell model of tauopathy [108], in spinal spinocerebellar ataxia (SCA) type 17 cells, and in SCA17 mouse models [109].