The 4M tetrameric form LDHA, due to the higher affinity to pyruvate, catalyzes the conversion of the latter to lactate during cell aerobic glycolysis; therefore, its aberrant expression and activation have been found to be related to different types of cancers [20,21], whereas LDHB controls the oxidation of lactate to pyruvate in the process of cell aerobic glycolysis in the heart and brain. This evidence concerns the gene LDHA and cancer.