AKT1 and brain ischemia: In addition, the anti-cerebral ischemia effect of A. sinensis and ligustilide has been applied mainly by activating the phosphorylated protein kinase B (Akt)/mammalian target of rapamycin (mTOR) signal transduction pathway and regulating the expression of autophagy protein (p-Akt, p-m TOR, and p-P70S6K) [44,45].