Tumor-associated macrophages (TAMs) in the tumor microenvironment tend to be M2 polarization [5,6] and secrete cytokines such as IL-10 and TGF-β to suppress immune cells and stimulate angiogenesis [7] and chemoresistance [8] to promote tumor invasion and metastasis, which usually results in a poor prognosis for the patient. This evidence concerns the gene IL10 and neoplasm.