As shown in Figure 2, compared with the BC group, RRFA at 3% concentration significantly increased the mRNA levels of COL1, COL3 and elastin genes, with upregulation rates of 17%, 47%, and 159%, respectively; RRFA at 1.25% concentration significantly increased the mRNA levels of COL3 and elastin genes, with upregulation rates of 15% and 65%, respectively. Here, ELN is linked to breast cancer.