Activating the AMPK/GSK-3β signaling pathway can increase the nuclear translocation of Nrf2, upregulate the transcription of HO-1, solute carrier family 7 member 11 (SLC7A11) and glutathione peroxidase 4 (GPX4), and reduce the expression of caspase 3 which, in turn, can combat oxidative stress, ferroptosis and cell apoptosis in myocardial ischemia/reperfusion (I/R) [66,67]. The gene discussed is GPX4; the disease is myocardial ischemia.