In the isoproterenol (ISO)-induced MI rat model, rats orally administered LU showed MI size, lipid peroxidation product MDA, cardiac diagnostic marker enzymes (cTnT, CK-MB and LDH), inflammatory factors (IL-1β, TNF-α, NF-κB p65 and IL-6) and apoptosis related markers (caspase-3 and caspase-9) were significantly decreased, while the activities of cardiac antioxidants SOD and catalase (CAT) were increased. Here, CASP3 is linked to myocardial infarction.