CASP3 and myocardial ischemia: In exploring the anti-apoptotic and antioxidant mechanisms of Pae and danshensu combination (PDSS) in the treatment of ischemic heart disease (IHD), it was found that PDSS not only significantly reduced the histopathological changes in rat myocardial tissue sections induced by ISO, but also decreased ROS, Bax, thiobarbituric acid reactive substances (TBARS), TNF-α, Fas, caspase-8 and caspase-3 levels, while significantly increasing the glutathione/oxidized glutathione (GSH/GSSG) ratio and Bcl-2.