HMOX1 and myocardial infarction: Importantly, RUS treatment increased the expression of branched-chain amino acid transaminase 1 or 2 (BCAT1 and BCAT2) in patients with MI; conversely, BCAT1 or BCAT2 siRNA induced the degradation of Nrf2 and HO-1 in cardiomyocytes and promoted ferroptosis [122].