In summary, different natural products can protect the heart by regulating Nrf2/HO-1, AMPK, PI3K/Akt, NF-κB, Sirt, ERK, JNK and other related signals, such as enhancing cardiac remodeling, improving MI, alleviating MI, and protecting I/R-induced myocardial apoptosis (Table 2). The gene discussed is AKT1; the disease is myocardial infarction.