NFE2L2 and myocardial infarction: In addition to its anti-inflammatory activity, it also upregulates the levels of superoxide dismutase (SOD) 2, NQO1 and glutathione peroxidase (GPX) by activating Nrf2/HO-1 signaling, while reducing the transcription of p67 phox, Gp91 and NADPH oxidase 4 (NOX4), thereby inhibiting oxidative stress after myocardial infarction [91].