Inactivation of NF-κB signaling can inhibit the release of inflammatory cytokines, reduce cardiomyocyte apoptosis and interstitial fibrosis, reduce the susceptibility to ventricular arrhythmias, and improve cardiac function [76], which revealed that the pathogenic role of NF-κB in cardiac ischemic injury and pathological remodeling [77]. The gene discussed is NFKB1; the disease is Ventricular arrhythmia.