CASP3 and myocardial infarction: Similarly, inhibition of Phosphatase and tensin homolog (PTEN, a negative regulator of PI3K/Akt) can reduce the expression of caspase-3, caspase-7, and caspase-9, while increasing the expression of B cell lymphoma-2 (Bcl-2) in cardiomyocytes of MI mice, ultimately enhancing the protective effect of mice against ischemic injury after MI and reducing inflammation and myocardial remodeling [70].