TRPV4 and osteoarthritis: Transient receptor potential vanilloid type 4 (TRPV4), belonging to the TRP superfamily, is expressed in immune cells, sensory neurons, glial cells, the spinal cord, cortical pyramidal neurons, etc. This channel is associated with inflammatory diseases that affect the central and peripheral nervous system, such as osteoarthritis, atherosclerosis, cancer pain, and neuropathies [33].