CYCS and acute lymphoblastic leukemia: Also, it affected HL-60 (human promyelocytic leukemia cells), K562 (chronic myelogenous leukemia), Molt-3 (acute lymphoblastic leukemia) and COLO320 (adenocarcinoma of the colon) by DNA damage, and these processes eventually led to apoptosis through the activation of caspases (3, 8 and 9) and caused the release of cytochrome C [33,34,35,36].