Solinas et al. [36] found that CBD in glioma U87-MG cells significantly interfered with and decreased the protein expression of various regulatory factors involved in the angiogenic process, such as vascular endothelial growth factor (VEGF), matrix metalloproteinase-2/9 (MMP-2/9), matrix metalloproteinase inhibitor-1 (TIMP-1), urokinase-type fibrinogen activator (uPA), etc., but no specific signaling pathway was identified. This evidence concerns the gene MMP2 and central nervous system cancer.