CBD also upregulates acute myeloid leukemia (AML)-1 transcription factors, binds to the transient receptor potential Vanilloid-2 (TRPV2) promoter in a PI3K/AKT-dependent manner, and activates TRPV2 to trigger the differentiation of glioma stem cells (GSCs), which activates the autophagy process and inhibits GSC growth [33]. The gene discussed is TRPV2; the disease is central nervous system cancer.