In colon cancer cells, CBD induces ERS and increases the expression of death receptor DR5 by phosphorylating the double-stranded RNA-dependent protein kinase-like ER kinase-C/EBP homologous protein (PERK-CHOP) while also enhancing tumor cell apoptosis induced by tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) [18]. This evidence concerns the gene TNFSF10 and neoplasm.