EGF and breast carcinoma: CBD inhibits the activation of the EGF/EGFR signaling pathway and the activity of its downstream targets, AKT, ERK, and NF-κB to inhibit tumor cell proliferation and, at the same time, inhibits breast cancer cell invasion and migration through the downregulation of MMP- 2 and MMP-9 secretion, inhibiting breast cancer cell invasion and migration [32].