The relative expression levels of the tumour marker NLRP3 mRNA in the canine mammary carcinomas are highly significant (p < 0.01) when compared with those in the benign mammary tumours and the paraneoplastic controls, and the differences between the benign mammary group and the paraneoplastic control group are not significant (p > 0.05). Here, NLRP3 is linked to neoplasm.