SP100 and type 2 diabetes mellitus: Among the other illnesses potentially heightening the overall cardiovascular risk factors in PBC subjects, we can find hypertension and T2DM (besides dyslipidemia, as already indicated in the paragraph above), with hypertension playing an apparently significant role in worsening these patients’ outcomes; in particular, anti-sp100 antibodies considered specific for PBC were found associated with adverse outcomes in PBC subjects [77].