Among the other illnesses potentially heightening the overall cardiovascular risk factors in PBC subjects, we can find hypertension and T2DM (besides dyslipidemia, as already indicated in the paragraph above), with hypertension playing an apparently significant role in worsening these patients’ outcomes; in particular, anti-sp100 antibodies considered specific for PBC were found associated with adverse outcomes in PBC subjects [77]. The gene discussed is SP100; the disease is hypertensive disorder.