In general, at least four conditions have been described in which a high concentration of Lp-X leads to the development of dyslipidemia: (a) cholestasis (regardless of triggering causes), (b) LCAT deficiency, (c) infusion of lipid-rich solutions, and (d) graft vs. host disease in liver transplant patients [56]. The gene discussed is LCAT; the disease is cholestasis.