FNDC5 and fatty liver disease: Similarly, some other proteins secreted by the adipose tissue are intricately involved in liver dysregulation, contributing to disease development and progression; among these, we can find adiponectin (decreased in subjects with fatty liver diseases and inversely correlated with the severity of hepatic steatosis), ghrelin (its lower levels in MASLD subjects are associated with insulin resistance), leptin (which is positively correlated with steatosis severity), and resistin, irisin, and visfatin (which are all generally increased in steatotic livers) [25].