CCM2 and cerebral cavernous malformation: Familial cerebral cavernous malformations (CCM) is a heritable autosomal dominant disease characterized by at least three mutations in three different loci as follows: CCM1 on chromosome 7q, CCM2 on chromosome 7p, and CCM3 on chromosome 3p, characterized by vascular abnormalities in the central nervous system (CNS), leading to epileptic seizures and hemorrhagic strokes [176,177,178,179].