Laboratory criteria for APS diagnosis include the presence of lupus anticoagulant in plasma, medium- or high-titer anticardiolipin antibodies (IgG or IgM isoforms), and medium or high anti-beta 2 glycoprotein I antibodies (IgG or IgM isoforms) on two occasions at least 12 weeks apart [4,6,10,11,12,13,14,15]. Here, CD40LG is linked to autoimmune polyendocrinopathy.