CTLA4 and neoplasm: The schema for this is shown in Figure 2A, the survival curves are shown in Figure 3A, the tumor response rate is shown in Figure 3B and the tumor growth curves for all animals in each of the 5 separate treatment groups are shown in Figure 3C. The survival curves in Figure 3A show that eliminating the combination of anti-CD40 and anti-CTLA-4, or eliminating the combination of CpG and anti-CD40, each bring the survival down dramatically and significantly compared to the full CAIR regimen; neither curve is significantly better than the RT alone group.