Steroids, such as prednisolone, prednisone, ACTH, methylprednisolone, and hydrocortisone have been employed in the treatment of various seizure disorders, including epileptic spasms [42,43,44,45,46,47], epilepsy syndromes with spike-and-wave activity in sleep [13,48,49,50,51,52], Lennox-Gastaut syndrome [10,23,27,53,54], drug-resistant epilepsies [25,55,56,57,58,59], and status epilepticus [60,61]. Here, POMC is linked to Lennox-Gastaut syndrome.