MIF and neoplasm: This idea of MIF-dependent regulation of Th17 cells was furthered by examining tumor-derived MIF expression in nasopharyngeal carcinoma; MIF involvement in the development, recruitment, and migration of intertumoral Th17 cells was mainly dependent on the mTOR pathway and the interaction of MIF with CXCR4 and was associated with a more favorable outcome in patients [75].