As a result, collagen (COL1A1, COL1A2, COL3A1, COL4A1, and COL5A1), matrix metalloproteinase (TIMP1 and MMP), and chemokine (CCL3, 4, 5, and CXCR4) target genes were expressed in CAFs, leading to increased desmoplastic reactions in HCC. The gene discussed is CCL3; the disease is hepatocellular carcinoma.