In CCA, fibroblast activation protein (FAP) + CAFs promote myeloid-derived suppressor cell infiltration [112], whereas the stromal-derived factor (SDF)1a-CXCR4 pathway is involved in CAF-mediated monocytes’ infiltration and differentiation within HCC tumors [113]. This evidence concerns the gene CXCL12 and hepatocellular carcinoma.