In this study, we investigated the impact of SVZ, SGZ and cortex involvement of 177 IDH wildtype glioblastomas on survival, as well as their relation to other clinical variables, such as KPS score, epileptic seizures at initial diagnosis, multifocality and selected molecular markers (MGMT promotor methylation status and Ki-67 proliferation index). This evidence concerns the gene MGMT and glioblastoma.