Somatotroph tumors secrete growth hormone and cause acromegaly, lactotroph tumors secrete prolactin and induce hyperprolactinemia, thyrotroph tumors produce excess thyroid stimulating hormone (TSH) and lead to mild central hyperthyroidism, corticotroph tumors secrete adrenocorticotrophic hormone and cause Cushing’s disease (CD) and a small number of gonadotroph tumors secrete intact follicle-stimulating hormone (FSH) or luteinizing hormone (LH) and may cause sexual dysfunction and hypogonadism. This evidence concerns the gene GH1 and acromegaly.