Notably, the degradation of ATAD2 protein was observed in cell lines harboring mutant VHL, like clear cell renal cell carcinoma-derived cell lines, RCC4 and 786-O, upon hypoxic treatment, indicating that the regulation of ATAD2 protein was independent of the pVHL–HIF axis and its downstream genes [4]. The gene discussed is VHL; the disease is clear cell renal carcinoma.