It has been reported that HIF-1 induces the expression of a member of the IAP family protein, Survivin, and conversely suppresses the expression of Caspase-9, which is involved in the induction of cell death via the intrinsic apoptosis pathway, thereby enhancing the anti-apoptotic potential of hypoxic cancer cells and leading to resistance to anticancer drugs [45]. This evidence concerns the gene HIF1A and cancer.