PCA3 and cancer: Of these, ExoMeth, which combines serum PSA, hypermethylation within the urinary cell pellet as assessed by methylation targets (GSTP1, APC, SFRP2, IGFBP3, IGFBP7, PTGS2), and EV-RNA transcripts (ERG exons 4–5, ERG exons 6–7, GJB1, HOXC6, HPN, PCA3, SNORA20, TIMP4, TMPRSS2/ERG fusion), gave particularly promising results for detection of any cancer on biopsy (AUC 0.91) and stratifying Gleason 3 + 4 or above on initial biopsy (AUC 0.89) [134].