Kaempferol downregulates the expression of cytokine signaling-3 (SOCS-3), PI3K-AKT-mTOR, miRNA-21, signal transducer and activator of transcription-3 (STAT-3), phosphorylated-mTOR signaling pathways, and HIF-1 in HCC. This evidence concerns the gene STAT3 and hepatocellular carcinoma.