As prospective therapeutic targets for patients with refractory GC receiving cisplatin-fluorouracil (CF) combination chemotherapy, the biomarkers Centromere Protein B (CENPB), Metastasis-Associated 1 (MTA1), Glucosaminyl (N-Acetyl) Transferase 3, and Mucin Type (GCNT3) are promising in terms of clinical use. This evidence concerns the gene GCNT3 and gastric cancer.