For example, in MM cells, the reduced poly(A) activity of different FAM46C mutants does not always correlate with impaired tumour suppressor phenotypes [65], and mutants predicted not to affect FAM46C poly(A) activity actually suppress FAM46C-induced phenotypes [21], suggesting that FAM46C poly(A) activity itself is not sufficient to fully explain its tumour suppressor effects. The gene discussed is TENT5C; the disease is Miyoshi myopathy.