The last model we will discuss was suggested by our lab [21] and proposes that, by localizing at the ER thanks to interaction with fibronectin type III domain containing 3A and 3B (FNDC3A and FNDC3B) [21,66], two proteins known to be involved in cell development [76,77], but also with disease [78,79], and specifically cancer [80,81,82,83,84,85], FAM46C regulates intracellular trafficking (Figure 1C). This evidence concerns the gene TENT5C and cancer.