Mroczek and colleagues demonstrated that, in MM cells, re-expression of wt FAM46C, but not of a loss-of-function allele, induced cell death and that FAM46C silencing favoured proliferation [20]; Herrero and colleagues demonstrated that either FAM46C knockout or down-modulation favoured MM cell invasion and migration [30]; and Kanasugi et al. demonstrated that knockout of FAM46C inhibited apoptosis and favoured cell cycle progression of MM cells [13]. This evidence concerns the gene TENT5C and Miyoshi myopathy.