All FAM46 proteins are also involved in cancer, with FAM46A being found associated with non-small cell lung cancer (NSCLC) [32], glioma [33], oesophageal [34] and ovarian carcinoma [35], FAM46B with prostate cancer [36,37] and NSCLC [38] and FAM46D with gastric cancer [39]. Here, TENT5B is linked to central nervous system cancer.