Instead, FAM46C expression triggered a significant alteration of intracellular vesicle transportation dynamics, with consequent deregulation of non-canonical protein secretion and autophagy, the latter effect causing accumulation of intracellular protein aggregates, an event that in already ER-stressed MM cells induced apoptosis, well explaining FAM46C tumour suppressor role. Here, TENT5C is linked to Miyoshi myopathy.