So, in highly secreting B cells or myeloma cells, where Ig secretion is key, FAM46C might be mainly involved in transcript stabilization and in organization of intracellular trafficking dynamics, while in cells, like melanocytes, in which secretion is less relevant, FAM46C might mainly exert its function by modulating centriole structure and duplication, an event which is similarly recapitulated in spermatids, where FAM46C is involved in maintaining the correct structure of the microtubule-derived manchette. This evidence concerns the gene TENT5C and plasma cell myeloma.