To further strengthen the FAM46C-MYC connection stand the previously discussed rearrangements, frequently found in MM patients, which occur between the FAM46C super-enhancer locus and the MYC promoter (see the “The FAM46C gene and its mutations in cancer” section), which have the opposite effect of hyperactivating MYC through FAM46C inactivation. This evidence concerns the gene MYC and Miyoshi myopathy.