FAM46 proteins were indeed already shown to be involved in protein stability, as FAM46C antiviral activity was shown to depend on autophagic dampening, an event which in turn was proposed to render viral proteins more susceptible to proteasomal degradation [4], and FAM46B was demonstrated to favour ubiquitination of β-catenin in BC cells [36]. This evidence concerns the gene TENT5C and breast cancer.