Fucci and colleagues, in their 2020 paper, showed that down-modulation of PRDM1 caused a drastic reduction in FAM46C protein levels in MM cells [66], while Li and colleagues instead found that loss of HIC1 correlated with decreased FAM46C levels in LC [63], suggesting that HIC1 might positively regulate, possibly indirectly, transcription of FAM46C. This evidence concerns the gene TENT5C and Miyoshi myopathy.