TRPV4 and neuropathy: In addition, the blockage of Ca2+ influx through TRPV4 channels with antagonist HC-067047 prevented cell death in cultured neurons, averted the electrophysiological and behavioral changes associated with paclitaxel-induced neuropathy [115], and partially attenuated the mechanical allodynia and oxidative stress evoked by paclitaxel in preclinical models [79].