Research efforts have been made in the discovery and development of TRPV4 antagonists as medicines, and many patent publications on TRPV4 antagonists describe its therapeutic applications in a multitude of pathologies, including pain, glioma, spinal cord injury, cerebral edema, cough, heart failure and ischemic heart disease, and dermatological conditions, among others [88]. This evidence concerns the gene TRPV4 and heart failure.