KMT2A and acute myeloid leukemia: Structural variants (SVs) affecting the Lysine (K)-Specific Methyltransferase 2A (KMT2A) gene, formerly known as MLL (myeloid/lymphoid or mixed-lineage leukemia), on chromosome band 11q23.3 are recurrently encountered in acute myeloid leukemia (AML) and are often indicative of early relapse and an overall poor prognosis [1,2,3,4,5,6].