Another proteomic study identified 11 unique proteins, including five upregulated in non-relapsed HL (e.g., isoform 2 preproprotein of complement C4-A, complement C4-B, fibrinogen γ chain, inter-α-trypsin inhibitor heavy chain H2, and immunoglobulin heavy chain constant region mu) and six upregulated in relapsed HL (e.g., apolipoprotein A-I, apolipoprotein A-IV, clusterin, haptoglobin, α-1-acid glycoprotein 1, and transthyretin) [98]. The gene discussed is C4B; the disease is Hodgkins lymphoma.