EV-miRNA profiling revealed that IGF2BP3 silencing of Ewing’s sarcoma cells altered specific miRNAs associated with the PI3K/Akt pathway in recipient cells [127], including miR-223-3p which target IGF1R, a major driver of EWS aggressiveness and a previously reported target of IGF2BP3. This evidence concerns the gene EWSR1 and Ewing sarcoma.