In this direction, Zhu et al. [74] reported that increased levels of EV-derived miR-181a-5p, miR-125b-5p, and let-7b-5p were associated with in vitro invasion and migratory abilities of SHH medulloblastoma cells through the activation of ERK in the Ras/MAPK pathway [74]. Here, MAPK1 is linked to medulloblastoma.