ACY1 and malignant colon neoplasm: As an actin severing protein, rapidly dividing cells demonstrate decreased expression levels of Scin, as tumorigenic cells have a tendency to migrate, and other studies have also shown that the expression of Scin, like aminoacylase-1A (Acy1; active in colorectal cancer cell migration) is associated with cell proliferation changes [37] and colon cancer survival in humans [38,39].