The expression of carbamoyl-phosphate synthase [ammonia], mitochondrial (Cps1; involved in mitochondrial energy pathways), has been shown to be inversely correlated with tumor development in the context of gastrointestinal cancer and its downregulation is linked to shorter patient survival, and, in intestinal-type cancers specifically, it is associated with advanced tumor stages [54]. The gene discussed is CPS1; the disease is neoplasm.