THBS1 and hematopoietic and lymphoid cell neoplasm: Since the transmembrane protein CD47 is overexpressed in many types of hematologic cancers and especially in ALL, where it is able to drive cell death processes through its binding to the signal regulatory protein α (SIRPα) or thrombospondin-1 (TSP1), the use of the first-described serum-stable CD47-agonist peptide PKBH1 has been shown to induce ICD in ALL [146].