Furthermore, the small molecule APO866, an inhibitor of nicotinamide phosphoribosyltransferase (NAMPT) and NAD+ biosynthesis, can induce parthanatos in AML models by NAD+ depletion, mitochondrial polarization, and PARP-1 activation, alone and in combination with ETO [191]. This evidence concerns the gene NAMPT and acute myeloid leukemia.