Notably, while caspase 8 deletion sensitizes AML cells to Birinapant, the combined loss of caspase 8 and necroptosis effector MLKL prevents Birinapant/IDN-6556-induced death, demonstrating that caspase 8 inhibition sensitizes AML cells to Birinapant-induced necroptosis [116]. The gene discussed is MLKL; the disease is acute myeloid leukemia.