The mushroom-derived component poricoic acid (PAA) triggers, in T-ALL cells, the activation of the autophagy process via the AMPK/mTOR/ Microtubule-associated protein 1A/1B-LC3, and in secondary ferroptosis via the GSH depletion and GPX4 inhibition [162]. The gene discussed is GPX4; the disease is acute lymphoblastic leukemia.