In the study hereby presented, the stable overexpression of the G protein-coupled transmembrane receptor GIPR, shown to be upregulated following the overexpression of TFF1, resulted in significantly increased apoptosis levels and a concomitant decrease in cell viability, growth, and proliferation in vitro as well as tumor growth in vivo, suggesting a tumor suppressor role of GIPR in RB. The gene discussed is TFF1; the disease is neoplasm.