CEACAM5 and neoplasm: The classical predictors included in this model, namely nodal status of the primary tumour, disease-free interval from detection of the primary to discovery of the liver metastases < 12 months, number of tumours greater than one, preoperative carcinoembryonic antigen (CEA) level > 200 ng/mL and size of the largest tumour > 5 cm retain their significance in a large percentage of modern CRLM studies.