While the role of the different STOML2, ARHGAP2, and HSF2 protein isoforms is not fully understood, the ratio of LYNA and LYNB protein isoforms has been reported to have an effect on breast cancer patient survival [58], at least in part because the LYNA and LYNB isoforms confer different migratory and invasive properties to breast cancer cells. The gene discussed is CHN1; the disease is breast carcinoma.