In order to analyze whether LINC01021 affects the transcriptional program of p53 independently from the direct feedback regulation of p53, we studied the effect of CRISPR/Cas9-mediated abrogation of p53-induced LINC01021 transcription on genome-wide RNA expression changes after the activation of ectopic p53 in CRC cells by RNA-Seq analyses. Here, TP53 is linked to colorectal carcinoma.