We and others previously reported that LINC01021 (also known as PURPL for p53 up-regulated regulator of p53 levels) is a p53-inducible lncRNA that affects the cellular response to genotoxic drugs, since the loss of LINC01021 in p53-proficient colorectal cancer (CRC) cell lines resulted in increased sensitivity to DNA-damaging chemotherapeutics, suggesting a pro-survival function of LINC01021 [23,24,25]. This evidence concerns the gene TP53 and colorectal cancer.