Notably, mRNAs up-regulated in LINC01021 KO but not in wild-type cells were highly enriched for genes up-regulated upon the siRNA-mediated depletion of EZH2 in the PC3 prostate cancer cell line (NYUTTEN_EZH2_UP, ref. [46]) or the depletion of HDAC3 in the U2OS osteosarcoma cell line (SENESE_HDAC3_UP, ref. [47]) (Figure 3A). This evidence concerns the gene EZH2 and Familial prostate cancer.