The authors discovered that, in the context of glioma, PTX3 can recruit multiple immune infiltrating cells and stromal cells, including CD4+/CD8+ T cells, NK cells, macrophages, fibroblasts, and endothelial cells, suggesting that high expression of PTX3 may promote T reg differentiation and inhibit the proliferation of T cells [36]. This evidence concerns the gene PTX3 and central nervous system cancer.