It has been confirmed that PTX3 Is associated with many non-malignant conditions that include stroke, sepsis, hepatic cirrhosis, systemic lupus, atherosclerosis, and rheumatoid arthritis, with eventual overexpression in different types of tumoral conditions including breast, lung, prostate, gliomas, and hepatic cancer [31,32,33,34]. This evidence concerns the gene PTX3 and glioma.