FN1 and colonic neoplasm: Consistent with our findings, Miyazaki et al. independently identified integrin α5β1 in cancer cells and fibronectin in CAFs as key molecules mediating CAF adhesion of pancreatic, lung, and colon cancer cells [40,41], and they showed that blocking integrin α5β1 or fibronectin hampers CAF-led cancer cell invasion in the 3D co-culture system.