The SWI/SNF chromatin remodeling complex is a large and versatile protein complex, composed of many subunits, which regulates replication and transcription, as well as facilitates repair of DSBs by homologous recombinational repair or non-homologous end joining; thus, it has a potential role as a tumor suppressor [34,42,43]. Here, SMARCA1 is linked to neoplasm.