Ali et al. (2020) quantified 37 proteins in 483 tumors from the METABRIC cohort [73], while Jackson et al. (2020) demonstrated the superiority of single-cell pathology over traditional IHC in analyzing tumor tissue of 352 patients for 35 clinically established targets, including ER, PR, and HER2 [74]. This evidence concerns the gene ESR1 and neoplasm.