Based on the genetic data of 4419 (of 4489) plasma proteins from UK Biobank, our study presents compelling evidence linking 10 plasma proteins (GSTO1, LIRB4, PIGF, IL‐21, MICB, PDE4D, RGAP1, TLR4, UBP25 and CBR1) to childhood asthma. The gene discussed is IL21; the disease is childhood onset asthma.