Based on the genetic data of 4419 (of 4489) plasma proteins from UK Biobank, our study presents compelling evidence linking 10 plasma proteins (GSTO1, LIRB4, PIGF, IL‐21, MICB, PDE4D, RGAP1, TLR4, UBP25 and CBR1) to childhood asthma. Here, CBR1 is linked to childhood onset asthma.